Evidence-based mostly medicine is efficacious to the extent which the evidence foundation is comprehensive and impartial. Selective publication of scientific trials — and the outcomes inside of All those trials — can lead to unrealistic estimates of drug usefulness and alter the obvious hazard–profit ratio.
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Our literature-research technique consisted of the subsequent steps: a research of posts in PubMed, a search of references mentioned in evaluation content articles, in addition to a lookup of the Cochrane Central Sign-up of Managed Trials; Get in touch with by phone or e-mail Along with the drug sponsor's health care-info Division; And eventually, Get hold of through a Licensed letter despatched into the sponsor's healthcare-info Division, together with a deadline for responding in producing to our question about if the study effects had been published.
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